Usefulness of fasting plasma glucose to predict mortality or coronary heart disease in persons ≥60 years of age without diabetes mellitus or in those with undiagnosed diabetes mellitus (from the Dubbo Study)

The Dubbo Study

Article Title		Usefulness of fasting plasma glucose to predict mortality or coronary heart disease in persons ≥60 years of age without diabetes mellitus or in those with undiagnosed diabetes mellitus (from the Dubbo Study)
Article Authors		Simons LA; Simons J; Friedlander Y; McCallum J
		Link to PubMed for abstract
Article Journal		Am J Cardiol 2008;102:831-834
Article Synopsis		The role of fasting plasma glucose (FPG) levels below accepted diabetes “thresholds” in predicting mortality or coronary heart disease (CHD) is unclear, with this relationship being potentially confounded by age and gender differences and the presence of undiagnosed diabetes in so called non-diabetic population. This study examines whether FPG predicts mortality or CHD in subjects without diabetes or in those with undiagnosed diabetes (or lesser degree of glucose intolerance). FPG predicted higher mortality and CHD incidence in women with previous cardiovascular disease (CVD) but with no diabetes. FPG in the range 95-108 mg/dl (5.3-6.0 mmol/l) in a non-diabetic woman is of prognostic significance for survival or CHD if she has previous CVD, whereas FPG is of prognostic importance for survival if she has undiagnosed diabetes. FPG did not significantly predict any outcomes in non-diabetic men.